肝细胞癌的免疫治疗进展
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1.安徽医科大学第一附属医院 肿瘤内科,安徽 合肥 230022;2.哈佛大学医学院附属麻省总医院 Edwin. L. Steele肿瘤生物学实验室/放射肿瘤科,美国 波士顿 02114;3.中山大学附属第一医院 肝胆胰外科中心,广东 广州 510080;4.山东省肿瘤医院/山东第一医科大学附属肿瘤医院 消化肿瘤科,山东 济南 250117;5.浙江省人民医院/杭州医学院附属人民医院 肝胆胰外科及微创外科,浙江 杭州 310014;6.浙江大学医学院附属邵逸夫医院 普外科,浙江 杭州 310009;7.休斯敦卫理公会学术研究所 移植肿瘤学与治疗学中心/外科学系,美国 休斯敦 77030

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Advances in immunotherapy for hepatocellular carcinoma
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1.Department of Oncology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China;2.Edwin. L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA;3.Center of Hepato-Pancreato-Biliary Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China;4.Department of Gastroenterology Oncology, Shandong Cancer Hospital and Institute/Shandong First Medical University and Shandong Academy of Medical Sciences, Ji'nan 250117, China;5.Department of Hepatobiliary Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People's Hospital/Affiliated People's Hospital, Hangzhou Medical College, Hangzhou 310014, China;6.Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou 310009, China;7.Transplant Oncology and Therapeutics Program, Department of Surgery, Houston Methodist Academic Institute, Houston, TX 77030 USA

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    摘要:

    原发性肝癌(PLC)是全球发病率和病死率均较高的常见恶性肿瘤。肝细胞癌(HCC)是PLC的主要类型,在亚洲多由乙型肝炎病毒感染引起。尽管近年来在靶向治疗和局部治疗方面取得了进展,但其5年生存率依然较低,提示现有治疗手段疗效有限。免疫治疗的出现,特别是免疫检查点抑制剂(ICI),为PLC患者带来了新的希望。然而,由于肝脏独特的免疫微环境,免疫治疗在HCC中的疗效仍面临严峻挑战。本文综述了近年来肝癌免疫治疗的研究进展,重点讨论ICI、联合治疗、新兴疗法以及未来的发展方向。

    Abstract:

    Primary liver cancer (PLC) is a prevalent malignancy with high incidence and mortality rates globally. Hepatocellular carcinoma (HCC), primarily resulting from hepatitis B virus infections in Asia, constitutes most PLC cases. Despite advancements in targeted therapies and localized treatments, the 5-year survival rate remains low, indicating limited efficacy of current approaches. The advent of immunotherapy, particularly immune checkpoint inhibitors (ICIs), has brought new hope for patients with PLC. However, the liver's unique immune microenvironment presents significant challenges to the effectiveness of immunotherapy in HCC. This article reviews recent research developments in liver cancer immunotherapy, focusing on ICIs, combination therapies, emerging treatments, and prospective future directions.

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李敏,刘信,袁丹丹,王建国,陈江,Dan Gabriel DUDA.肝细胞癌的免疫治疗进展[J].中国普通外科杂志,2025,34(8):1618-1632.
DOI:10.7659/j. issn.1005-6947.250478

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  • 收稿日期:2025-07-16
  • 最后修改日期:2025-08-07
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  • 在线发布日期: 2025-10-21