Objective:To explore the diagnosis and management of acute deep vein thrombosis(DVT) of lower extremity. Methods: The clinical data of 96 patients with DVT were analysed retrospectively. Results:The diagnosis rate of DVT by vascular color ultrasounography was 97.8%, by MVC/SVO ratio combined with air plethysmagraphy was 97.2%, and by ECT was 100%. The MVO/SVC ratio, and diameter of calf and thigh in surgery group and in non surgery group showed significant difference in 7 days after operation (P<0.01). In this series, the effect was excellent in 62 cases(64.6%), good in 25 cases (26.0%), bad in 3 cases (3.1%), and discharged oneself in 6(6.3%). Conclusions: Vascular color ultrasounography is the first choice of noninvasive examination . The air plethysmography is a objective, effective and noninvasive technique in the diagnosis and evaluation of treatment effect of DVT. Early embolectomy combined with thrombolytic and anticoagulant therapy can get good effect.