Objective:To study the perioperative treatment of intraand extrahepatic cholelithinsis in patients with liver cirrhosis . Methods : The clinical data of intraand extrahepatic cholelithinsis in patients with liver cirrhosis in our hospital in resent 10 years was retrospectively analyzed. Results :According to the preoperative examation, improving hepatic function（turn child class C to A or B）, correcting the coagulation disturbance,decreasing portal vein pressure preoperatively,and proforming operation carefully to reduce bleeding,and giving support treatment and liver care treatment to improve the liver function further postoperatively etc were made.Fifteen cases remained stones, 5 cases appearred chronic liver failure,2 cases appearred kidney failure ,the other 69 cases recovered well. Conclusions :If optimizing perioperative treatment is given, favorable effect might be obtained in intraand extrahepatic cholelithinsis in patients with liver cirrhosis.