Objective:To investigate the clinical and pathological charasteristic, and the operative indications of polypoid lesions of gallbladder (PLG). Methods: The clinical date of 297 patients with PLG comfirmed by pathologic examination were analyzed retrospectively.Results:In nonneoplasm lesions, 80.1% were less than 10mm in diameter, and 71.6% were multiple.However,most of tumorous polyps were single and more than 10mm in diameter. Conclusions:If PLG companied with following conditions,an operation should be considered:(1)Neoplastic polyps.(2)The patients age are over 50 years old, the PLG diameter ＞10mm, the PLG lie in the neck of gallbladder.(3)PLG complicated with clinical symptoms.(4)The PLG diameter increases or complicated with stones.But surgical treatment should be prudent for nonneoplasm PLG, especially cholesterol polys.