Objective:
To investigate the effect of surgical treatment for giant primary liver cancer.Methods:One hundred and fortysix cases of giant primary liver cancer received surgical treatment in recent 11 years ware analyzed retrospectively. Of them, 99 cases underwent irregular hepatectomy ，28 hemihepatectomy and 4 right hepatic trisegmentectomy .Including 19 cases received secondary resection after preoperative TACE,meanwhile 6 cases were underwent portal venous cancer thrombus extraction， 15 cases received biopsies and DDS only, Interoprative DDS
were performed in 105 cases. Result:The postoperative complications was 10.3%, the postoperative mortality was 1.4%.The 1-,3-,5- and 10year survival rates were 56.6%, 30.2% ，14.4% and 2.1% respectively. Conclusions: The main treatment of giant liver cancer is hepatcctomy.Combination with TACE，portal thrombus extraction and DDS can improve the longterm survival.