Objective:
To investigate if the prognosis of young patients with colorectal cancer (CRC) is influenced by their familial predisposition. Methods:The patients with CRC under 40 years old, underwent operation, had pathological diagnosis , family survey, followed up etc were selected into this research. According to familial predisposition they were divided into two groups: group A (with familial predisposition) and group B (without familial predisposition). Results:Among the 44 patients twelve were in group A, thirty-two in group B. The 5-year survival rate in group A and B was 83.30%(10/12) and 59.38%(19/32) respectively,the difference was significant between the two groups(χ2=5.64,P<0.05). The cases of well differentiated cancer and poorly differentiated cancer in group A and B were 8, 4 and 19,13 respectively. Adjusted for histopothology difference, the standard 5-year survival rate in group A and B was 84.09%(37/44)and 59.09%(26/44)respectively(χ2=6.68,P<0.05). Patients in Dukes stage A ,B and C were 3, 14 and 18. Adjusted for Dukes classification difference,the 5-year survival rate in group A and B was 88.64%(39/44) and 63.64%(28/44) respectively (χ2=6.58,P<0.05). Conclusions:The prognosis of young patients with CRC may be influenced by their familial predisposition. It is necessary to collect more cases of young patients in HNPCC families for further study and to compare them with sporadic cases to evaluate the prognosis of goung patients with CRC correctly.