ObjectiveTo investigate the diagnosis and therapeutic methods of primary tumors of duodenum(PTD). MethodsClinical data of 86 patients with primary duodenal tumors who were hospitalized in the First Affiliated Hospital of China Medical University during 26 years were analyzed retrospectively. Of all the tumors,18 cases were benign tumors and 68 cases were malignant tumors. ResultsThe clinical manifestationswere symptoms of bile duct obstruction, GI and nonspecific symptoms, and signs included fever, anemia and weight loss. The correct preoperative diagnostic rate by auxiliary examinations were:duodenalendoscopy 92％, air barium double radiography 89％, MRCP 85％, BUS 33％, CT 51％, MRI 75％, and duodenal endoscopy combined with air barium double radiography were 95%. Tumors were mostly located in the descending portion of duodenum(71 cases). Eighteen cases of benign PTDs were resected completelywith a 5year survival of 92.3%. Among the 68 maligant PTD cases, 35 cases underwent pancreatoduodenectomy, and 8 cases received segmental duodenectomy, with a resection rate of 63.2% and the 5year survival rate of 31.0%. The remaining 25 cases, in which the tumors were unresectable, were treated by bypass operations, the 5year survival rate was 0%. ConclusionsPatients with PTD usually lack specific symptoms and signs, but combination of endoscopy, GI air barium double radiography and other examinationscan improve the preoperative positive diagnostic rate. Segmental duodenectomy and simple tumor resection are curable for primary benign tumors of duodenum; while for primary malignant tumors of duodenum, the therapy of choice should be pancreatoduodenectomy.