Abstract:Objective:To investigate the preventive effects of 103Pd radioactive stent on stenosis after bile duct injury in dogs.Methods:Twelve healthy dogs (15~20kg) were randomly divided into 103Pd radioactive stent group (n=6) and control group (n=6). Immediately after balloon dilatation injury to the bile duct, the 103Pd radioactive stent(experiment group) or the ordinary stent(control group) was positioned into the target segment. The dogs were killed one month later. The injured bile duct segments were dissected free from the dogs, and were examined radionucleonically, immunohistochemically and pathologically. Muscular proliferation area and lumen area were determined by computer-assisted picture analysis system. Results:In the control group, 30 days after ductal injury, the mucosa of the bile duct was fractured, the mucosa was proliferated and the lumen stenosed.Compared with the control group, 103Pd radioactive stent significantly reduced muscular proliferation area (P＜0.01), decreased percentage of stenosis area ［(60±21.6)% vs (31.6±9.5)%］, and increased bile duct lumen area (P＜0.01). Conclusions:103Pd radioactive stent is feasible and effective in reducing muscular proliferation and preventing stenosis 30 days after balloon dilatation injury to the bile duct in dogs.