Abstract:Objective:To establish and assess a model of abdominal postoperative fatigue syndrome (POFS) in rats. Methods:After 70% hepatectomy was performed, the following observations of the animals were made:general condition, rat tail suspension test,weight-carrying swim fatigue test,serum levels of albumin,ferrition,and iron,pathologic assessment of injury of small intestinal mucosa and hepatic albumin gene expression.Results:After 70% hepatectomy of the rats,their general candition was poor,the level of physical tolerance decreased,they showed a certain amount of depression,and marked changes were found in nutritional index,stress injury of small intestinal mucosa and hepatic albumin gene expression.Conclusions:A 70% hepatectomy rat model has the basic characteristics of clinical abdominal POFS, and can be used as an experimental animal model for the study of abdominal POFS.