Objective:To investigate the effects of hemoglobin concentration on portal hypertension associated with hyperdynamic state. Methods:According to blood hemoglobin level below or above 110g/L, 55 nontreated portal hypertension patients were divided into anemic and nonanemic groups, and the relevant hemodynamic and clinical data were examined and analyzed retrospectively. In order to avoid the effects of differences in hepatic function, data were analyzed separately according to the Child class. Results:Compared to the nonanemic group, the anemic group had markedly increased cardiac output ［(7.4±1.7L)/min vs (6.3±1.9L)/min, P=0.028］ and increased free portal pressure ［(29.1±3.1)mmHg vs (26.8±3.3)mmHg, P=0.012］, and a markedly decreased mean arterial pressure ［(84±10.7)mmHg vs (97.1±12)mmHg, P<0.01］ and systemic vascular resistance ［(866±215)dyn/(s·cm5)vs (1207±317) dyn/(s·cm5), P<0.01］. Similar results were obtained when Child A and Child BC patients were analyzed separately. Multivariate logistic regression disclosed that hemoglobin concentration, as well as albumin concentration, was an independent factor influencing the systemic vascular resistance in PHT patients. Conclusions:Anemia further aggravates the hyperdynamic circulation of portal hypertension. Hemoglobin concentration is an important parameter to evaluate the hemodynamic status of PHT patients.