Abstract:Objective:To improve the diagnosis and treatment of primary duodenal malignant neoplasms(PDMN).Methods:The clinical data of 19 patients with primary malignant neoplasms of the duodenum were anayzed retrospectively.Results:The clinical manifestations were jaudice in 9 cases, upper abdominal pain in 7 cases, gastrointestinal hemorrhage in 6 cases,abdominal mass in 3 cases,and vomitting in 1 case. Diagnostic procedure and detection rate: The detection rate of PDMN by duodenoscopy was 83.3%(15/18), by hypotonic duodenography was 82.3%(14/17), 77.8%(7/9) by CT, and 1 case by MRI.16 cases underwent surgery with resection rate of 68.8 %(11/16).Pancreaticoduodenectomy was performed in 9 cases, simple tumor resection and regional lymphadenectomy in 1 case,resection of duodenal bulb plus partial gastrectomy in 1 case,and gastroenterostomy or choledochojejunostomy in 5 cases.The radical resection rate was 62.5%(10/16).The postoperative 1-,3-,and 5-year survival rate in radical resection patients was 90.0%(9/10)，40.0%(4/10) and 30.0%(3/10),respectively.In those with gastroenterostomy or choledochojejunostomy, the survival time was 6~15 months. Conclusions:Duodenoscopy and hypotonic duodenography are ideal tools for the diagnosis of all locations of PDMN.Pancreaticoduodenectomy might result in prolonged survival of patients with PDMN.