Abstract:Objective:To evaluate the value of regional infusion chemotherapy for prevention of local recurrence and hepatic metastasis after radical resection of gastric carcioma.Methods:352 patients with gastric carcinoma undergoing radical operation were preoperatively randomly divided into 2 groups:Regional infusion chemotherapy(treatment group,184 cases) and peripheral venous chemotherapy(control group,168 cases).Results:328 cases(93.2%) were followed-up for 3 to 6 years,and 24 cases were lost to follow up.The 1-,3- and 5-year survival rate was 95.7%,78.3% and 46.3%,respectively,in the treatment group,and 86.8%,48.2% and 22.0%,respectively in the control group.The local recurrence rate and hepatic metastasis rate was 9.2% and 12.5%,respectively,in the treatment group; and was 22.0% and 26.8%,respectively,in the control group.Conclusions:Regional infusion chemotherapy is effective for prevention of local recurrence and hepatic metastasis after radical operation for gastric carcinoma.It is better than peripheral venous chemotherapy and has less toxic side effects.