Objective：To compare the injury to hepatocarcinoma and normal liver tissues following ischemia and reperfusion. Methods：The hepatocarcinoma(HC) models were established by injectin of VX2 tumor tissue suspension fluid into the leftmiddle lobe of liver of rabbits. After the models were established, the models left hepatic vessels were occluded for 60 minus, then followed by various intervals of reperfusion, and the levels of superoxide dismutase (SOD) and malondialdehyde (MDA) were measured, and apoptotic changes in the hepatocarcinoma and normal hepatic tissues were observed by means of HE staining and TUNEL method. Results：The concentration of SOD decreased significantly in hepatocarcinoma tissue and reached the lowest point at 1h after ischemia and reperfusion (64.59±4.97NU/mgprot), then gradually rebounded, but, at 7d after reperfusion, it still retained at a lower level(121.12±6.88NU/mgprot) than that before reperfusion. In contrast with normal liver tissues,the concentration of MDA decreased in the hepatocarcinoma tissues following ischemia and reperfusion, the changs of MDA were similar to SOD. The apoptotic cells in hepatocarcinoma tissues increased to the highest point at 1 day following reperfusion, but 7d after reperfusion, the number of positive cells were more than before reperfusion, and the apoptotic rate was higher in hepatocarcinoma tissues compared with the normal liver tissues. Conclusions：In comparison with normal liver tissue, hepatocarcinoma tissue is more suscepible to the injury of ischemia and reperfusion.