Objective：To investigate the criteria and clinical significance of diagnostic classification of multiple organ dysfunction syndrome(MODS) in patients with severe multiple trauma. Methods：The clinical data of 132 cases of MODS resulted from severe multiple trauma(ISS>20) were analyzed.Results：MODS was staged according to “Lu shan conference” diagnostic criteria.In this group of patients there were 27 deaths(24.7%),of which 1 patient(3.9%) was stage I,7 patients(15.6%) stage II,9 patients(45%) stage III,and 10 patients(90.9%) stage IV.Prognosis varied with stage of MODS.The incidence of MODS increased with higher scores of body injury, and mortality rate increased with the increase of the number of failured organs.Conclusions： The diagnostic classification of MODS has obvious clinical significance. It provides clinicians with an important basis for early diagnosis and treatment of MODS.