Objective:To evaluate the effect of different skin flap management methods on post operative subcutaneous fluid collection and skin flap necrosis after modified radical mastectomy for breast cancer. Methods:A retrospectively analysis of clinical data of 119 cases of breast cancer operated by modified radical mastectomy in our hospital in recent four years. Statistically analyse the relationship between 4 different skin flap management methods to postoperative subcutaneous fluid collection and skin flap necrosis. Results:43 out of 119 cases developed postoperative subcutaneous fluid collection and/or skin flap necrosis. There were 13 cases with complication of subcutaneous fluid collection, 3 cases with skin flap necrosis among 79 cases treated by transverse incision；20cases with complication of subcutaneous fluid collection, and 7 cases of skin flap necrosis among 40 cases treated by longitudinal incision; 23cases with complication of subcutaneous fluid collection, and 8 cases of skin flap necrosis among 60 cases treated by “skin flap management type one”; 23cases with complication of subcutaneous fluid collection, and 2 cases of skin flap necrosis among 59 cases treated by “skin flap management type two”. Conclusions:A transverse incision after subcutaneous injection of 1∶〖KG-*2〗〖KG(*7〗400 adrenaline saline solution, plus the use of scalpel dissection and the technique of skin flap fixation by the “rivet” method can effectively decrease postoperative development of subcutaneous fluid collection and necrosis of incisional skin margins.