Objective:To investigate the growth inhibition and apoptosis induction effect of vitamin E succinate on MCF7 human breast cancer cells and to analyze the modulation of Fas expression in this process. Methods:Estrogen receptor positive MCF7 human breast cancer cells were treated with VES for 12h, 24h and 48h. The concentrations of VES were 5μg/mL, 10μg/mL and 20μg/mL. The inhibitory effect was measured with MTT method and the cell cycle and cell surface Fas expression were analyzed with flow cytometry. Fas protein level was detected by Western blotting assay. Results:VES had significant inhibitory effect on the growth of MCF7 human breast cancer cells and the effect was dependently related to time and dosage. The apoptotic rate rose from 1.2% to 11.2%、16.4%和41.2%,after treated with VES for 48h at the concentrations of 5μg/mL，10μg/mL和20μg/mL respectively. Fas protein level and cell surface Fas expression in cancer cells increased after the administration of VES. Conclusions:VES had significant growth inhibition and apoptosis induction effect on MCF7 estrogen receptor positive breast cancer cells. The mechanism was related to Fas upregulation on the surface of cancer cells.