Objective:To investigate the expression of FHITmRNA and WWOXmRNA in human breast cancer tissues and its relation to clinicopathological and other molecular parameters. Methods:With reference to the expression of βactin，the expression of FHITmRNA and WWOXmRNA was determined by reverse transcriptionpolymerase chain reaction(RTPCR) in 51 breast cancer and adjacent breast tissue, and semiquantitative analysis of band densities was performed. The protein expression of estrogen receptor(ER), progesterone receptor (PR), Her2 gene in the 51 breast cancer lesions was detected by immunohistochemical method. Results:FHITmRNA and WWOXmRNA expression was significantly different in 54 breast cancer tissue compared to adjacent breast tissue (P<0.01). The expression of FHITmRNA and WWOXmRNA in 51 breast cancer tissue was reduced and was related to the clinicopathological stage(P>0.05); of FHITmRNA and WWOX mRNA was related to axillary lymph node metastasis (P<0.05). There are correlations between the low expression of FHITmRNA and WWOXmRNA in breast cancer tissue. Conclusions:FHIT and WWOX are candidate tumor suppressor genes. Detected coordinately with other molecular parameters, they can make the prognosis of therapy more accurate to predict.