Abstract:Objective:To study the correlation of p53,ki-67 and bcl-2 expression in breast cancer with the clinical response to neoadjuvant chemotherapy, and search for biological markers to guide therapy and predict prognosis.Methods:The expression of the p53,ki67 and bcl-2 was examined by immunohistochemical assay in samples of breast cancer tissue which taken from 118 cases of operable breast cancer patients. The relationship between p53, ki-67 and bcl-2 and the effect of neoadjuvant chemotherapy was analyzed by chi-square test. Results:The overall response rate to neoadjuvant chemotherapy was 68.6%. Patients with expression of ki-67 were more likely to respond to treatment. The effect of neoadjuvant chemotherapy had a significantly negative correlation with p53 expression. There was no significant difference between the response to neoadjuvant chemotherapy and bcl-2 expression. Expression of p53 protein was correlated with low expression of bet-2. Expression of p53 and ki-67 protein was significantly related. Conclusions:The results indicated that p53 and Ki-67 expressions are strong prognostic molecular markers that can be a guide for neoadjuvant chemotherapy and prediction of prognosis for patients with breast cancer.