Abstract:Objective:To explore the expression of p130Cas and paxillin in human breast carcinoma and to investigate the relationships of p130Cas and paxillin levels with clinical and pathological characteristics. Methods:SP immunohistochemistry staining was applied to detect the expression of p130Cas and paxillin in tumor tissues from 53 cases of primary breast carcinoma, 10 cases of breast fibroadenoma and in 10 cases of normal breast tissues. Results:Breast carcinoma tissues showed higher levels of p130Cas（P<0.001）and lower levels of paxillin（P=0.003）than normal and fibroadenoma tissues. The expression of p130Cas was related with age, menopausal status, ER, PR status and histological grades, but not related with tumor size, lymph node status and pathological stages. The expression of paxillin was relateded with pathological stages, histological grades and lymph node status, but not related with age, menopausal status, ER, PR status and tumor size. Conclusions:p130Cas and paxillin have relations with the malignant transformation, invasion and metastasis of breast carcinoma. They can be used as useful factors in predicting the prognosis of breast carcinoma.