Abstract:Objective:To study the depressant effect of atorvastatin on arteriosclerosis of aortic allograft in rats. Methods:The models of abdominal aorta transplantation were established in rats with the use of micro-surgery. The recipients were divided into three groups:allograft control group, allograft experimental group and isograft control group. After 60 days of transplant, vascular intimal thickness(VIT) in all of the groups was observed by histological examination. The expression of PCNA and α-SMA was determined by immunohistochemistry. Results:The degree of VIT in rats of the allograft experimental group was lower than that in the allograft control group; the VIT area ratio in the allograft control group, allograft experimental group and isograft control group was （12.40±2.65）%, （5.20±6.35）%, and （1.2±1.10）%, respectively, A statistical difference between these groups was observed (P<0.05). The expression level of PCNA was lower in allograft experimental group (5.40±0.80)% than that in allograft control group (17.20±1.65)%(P<0.05). Conclusions:The expression of PCNA in the transplant aorta and the arteriosclerosis of aortic allograft could be suppressed by atorvastatin.