Abstract:Objective:To understand the clinical and pathological characteristics of hepatocellular carcinoma（HCC） with family aggregation (FH), and investigate the possible causes of HCC with FH aggregation.
Methods :The clinical and pathological data of 25 patients with HCC with FH and 39 patients with HCC with non-family aggregation(NF) were collected and compared.
Results:No significant difference was found in incidence of HCC, differentiation of tumor cells, the presence or absence of tumor capsule or venous tumor thrombosis, level of AFP and rate of recurrence at year after surgery between group FH and group NF (P>0.05). The gender ratio （male-to-female）、the HBV infection rate and the 3-year recurrence rate after surgery in Group FH was higher than that in Group NF（P＜0.05）. The average age、the pathological stage of liver fibrosis and HBV-DNA copy number in Group FH was lower than that in Group NF（P＜0.05）.
Conclusions:Genetic predisposition to disease and increased susceptibility to environmental carcinogens in the family may contribute to HCC with family aggregation.