Abstract:Objective:To study the effect of BMP-2 on apoptosis of human hepatoma HepG2 cells and the mechanisms.
Methods :Cell apoptosis was assessed by ELISA. Western blot was used to detect the expression of Bcl-2 and Fas proteins in HepG2 cells after treatment of BMP-2 .
Results:1～100ng/mL BMP-2 induced HepG2 cell apoptosis, and down-regulated Bcl-2 protein expression and increased Fas protein expression.
Conclusions:The present study suggests that BMP-2 induces HepG2 cell apoptosis may through Fas pathway.