Abstract:Objective:To observe the protective effect of PGE1 in rat ischemia-reperfusion injury and to investigate the possible mechanism.
Methods :After the model of in situ hepatic I/R injury was established in 24 rats, the rats were randomly divided into sham operation (S) group,ischemia-reperfusion(I/R) group and Prostaglandin E1 (PGE1) group.The serum concentrations of liver enzyme levels,superoxidase dismutase (SOD)，malondialdehyde(MDA) and myeloperoxidase(MPO) were measured respectively,and the hepatic pathological changes were observed.
Results:The liver enzyme levels，MDA and MPO were significantly higher，and activity of SOD was lower in groups of I/R and PGE1 group than those in S group (P＜0.01）.Compared with I/R group,liver functional parameters,MDA and MPO were lower in PGE1 group（P＜0.01）,and the activity of SOD was higher in PGE1 group（P＜0.01）; meanwhile，the hepatic congestion and pathological damage were also obviously relieved in PGE1 group.
Conclusions:PGE1 could relieve the I/R injury of liver,and the mechanism may be by improving tissue antioxidation capability and decrease of neutrophilic leukocyte aggregation.