Abstract:Objective:To investigate the role of hypoxia-inducible factor-1 alpha in portal hypertensive gastropathy through a study of the expression of hypoxia inducible factor-1 alpha in the gastric mucosa of portal hypertensive rats.
Methods :The portal hypertensive gastropathy models were established by portal vein-ligation, and sham-operated rats were used simultaneously as controls. The expression of HIF-1α、VEGF and CD34 in rat stomach tissues was detected by using immunohistology and MVD was counted under CD34 staining.
Results:The expression level of HIF-1α,VEGF and CD34 in the portal hypertensive gastropathy group was significantly higher than that in the sham-operated group (P<0.01).
Conclusions: The overexpression of HIF-1α may play an important role in the pathogenesis of portal hypertensive gastropathy.