Abstract:Objective:To investigate the correlation of pathologic factors with the prognosis of colorectal cancer patients with peritoneal dissemination and/or synchronous liver metastasis, and the effect of surgical intervention on the prognosis.
Methods :Based on our 12-year database, the clinicopathologic data and the result of follow-up of colorectal cancer complicated with peritoneal dissemination(150 cases) and/or synchronous liver metastasis(166 cases) were analyzed retrospectively.
Results:Multi-variate analysis indicated that peritoneal dissemination from colorectal cancer was associated with the depth of tumor infiltration and tumor differentiation, while liver metastasis was associated with tumor differentiation, depth of tumor infiltration and the Dukes staging（P＜0.01）.Both short-term and long-term overall survival rates showed no statistical difference between unresectable colorectal cancer patients with peritoneal dissemination and unresectable colorectal cancer patients with liver metastasis（P＞0.05）. However, in the resectable colorectal cancer patients,long-term overall survival of the patients with peritoneal dissemination was significantly better than those with liver metastasis（P＜0.01）.
Conclusions:Patients with peritoneal dissemination have better long term prognosis than those with liver metastasis in colorectal cancer.Only the unresectable peritoneal dissemination or liver metastasis is indicative of end-stage colorectal cancer. Radical resection of colorectal cancer with peritoneal dissemination has a better prognosis than radical resection for patients with synchronous liver metastasis. Radical excision could be achieved in patients with local peritoneal dissemination.