Objective:To investigate the efficacy of ultrasound ablation combined with autologous transplantation of bone marrow mononuclear cells in treatment of arteriosclerosis obliterans.
:Methods :Clinical data of 39 patients with arteriosclerosis obliterans treated with ultrasound ablation and autologous transplantation of bone marrow mononuclear cells were analyzed. There were 21 male and 18 female patients,With average age of 63 years. At operation, 260 mL of autologous bone marrow was withdrawn, mononuclear cells were separated, and 40 mL supension fluid of stem cells was prepared.Through percutaneous approach or surgical approach the ultrasound ablation catheter was inserted into occluded arterial segments. After ablation was performed, autologous bone marrow mononuclear cells were directly injected into the skeletal muscles of the ischemic leg.
:Results:No complications were found in this group. Postoperatively, rest pain of all the patients was significiently improved and distance of claudication increased.The skin became warm in all legs.
:Conclusions:Ultrasound ablation and autologous transplantation of bone marrow mononuclear cells is a simple, safe and effective method for treating patients with arteriosclerosis obliterans.