Abstract:Objective:To explore the clinical characteristics，diagnosis, treatment，and prognosis of male breast cancer.
Methods :The clinical data of 38 cases of male breast cancer, who were treated in the two hospital during the past 10 years, were analyzed retrospectively.The diagnosis was mainly based on preoperative B-ultrasound，radiography with molybdenum target tube and fine needle aspiration. Among the 38 cases, radical mastectomy was conducted in 3 cases，modified radical mastectomy in 27 cases，simple mastectomy in 5 cases，and operation was refused in 3 cases. Postoperatively, radiotherapy was adopted in 4 cases，simple endocrinotherapy in 7 cases，radiotherapy plus chemotherapy in 9 cases，and chemotherapy plus endocrinotherapy in 8 cases.
Results:Median age at treatment was 58.5 (53-82)years.TNM staging included stageⅠin 13 cases，stageⅡ in 19 cases，stageⅢ in 4 cases，and stageⅣ in 2 cases. Median follow-up was 73.8 months (2 months-10 years)，and follow-up rate was 73.6% (28/38). During the follow-up，13 cases died including 8 cases died of local recurrence and metastasis, and 5 cases died of heart and brain disease. The 5-and 10-year overall survival rate was 71.6% and 55.3% respectively;5-and 10-year disease-specific survival of stageⅠ，Ⅱ was 92.6% and 78.9% respeoively;among 6 cases of stageⅢ，Ⅳ 4 were followed，and all 4 cases died with in 3 years.
Conclusions:Male breast cancer has a long course，poor prognosis and low survival rate. Combined therapy with modified radical mastectomy, as its basis, is the treatment of choice for male breast cancer.There is a certain correlation between the prognosis of male breast cancer and clinical stage of the disease.