Abstract:Objective:To evaluate intra-artery transcatheter thrombolytic therapy for the treatment of acute lower extremity deep vein thrombosis (LEDVT).
Methods :A total of 68 patient with LEDVT were randomly divided into two groups to respectively receive intra-artial transcatheter thrombolysis (Group A), or intra-venous thrombolysis (Group B). The PT, FIB, D-dimer and the perimeter of limbs were examined and measured before and after treatment, the circumference difference between normal and affected limbs was measured to assess the reduction of edema, and the venous patency score and the patency improvement were observed by venograms or Duplex.
Results:No haemorrhage occurred during the treatment in Group A, but 4 patients in Group B had clinical haemorrhage. After treatment, increase of PT, and decrease of FIB and D-dimer was found in both groups (P<0.05). The reduction of edema in Group A after treatment was significantly more than that in Group B(P<0.01), and the mean rate of venous patency improvement was also significantly different(P<0.01)between the two groups［Group A (54.81±3.21)%,Group B (31.52±3.89)%］.
Conclusions:The preliminary experience suggests that intra-arterial transcatheter thrombolytic therapy is a safe and effective treatment for acute LEDVT.