Abstract:Objective:To investigate expression and clinical significance of HIF-1α、MVD and PCNA after TAE or TACE for rabbit liver carcinoma,and to identify the mechanism of hepatic carcinoma cell proliferation after the operation.
Methods :Thirty rabbits were implanted with liver VX2 tumors for 1 week.Then they were randomly divided into 3 groups．Control group had hepatic arterial infusion of 0.5 to 0.8 mL saline.TAE group was embolized with 0.5 to 0.8 ml UFLP. TACE group was embolized with 0.5 to 0.8 ml UFLP mixed with 2 mg THP. Two weeks after treatment, HIF-1α、MVD and PCNA expression was detected.
Results:Growth of the liver tumor was found in the 3 groups, and there were 15,11 and 3 new tumors found in the control group, TAE group and TACE group respectively. The expressions of HIF-1αand PCNA in control group were higher than those in TACE group,but significantly lower than those in TAE group（P<0.05）. The MVD in TAE group(115.3±20.74/ mm) was higher than that in control group (72.11±18.95/ mm)and TACE group(47.33±15.53/ mm) （P<0.05）.
Conclusions:The expressions of HIF-1αand PCNA were higher after TAE and can promote tumor growth. The expressions of HIF-1α and PCNA were lower after the TACE and can suppress tumor growth.