Abstract:Objective:To study the relation of RANTES and its receptor (CCR5) expression in gastric cancer and in lymph nodes with cancer metastasis.
Methods :The expression of CCR5 in gastric cancer and the expression of RANTES in lymph nodes were detected by the CCR5/DNA bivariate and RANTES/DNA bivariate by flow cytometry.
Results:The expression of CCR5 in gastric cancer and normal gastric tissue was (21.53±3.10)% and (10.10±1.30)% respectively（P＜0.05）; the positive rate of RANTES in lymph nodes with or without cancer metastasis was (63.50±5.25)% and (44.40±4.76)% respectively（P＜0.05）.
Conclusions:RANTES and its receptor might take part in modulation of gastric cancer metastasis.