Abstract:Objective:To summarize the experience of treatment of hilar cholangiocarcinoma.
Methods :The clinical data and long-term outcome of 96 cases of hilar cholangiocarcinoma were analyzed retrospectively.
Results:Out of 96 cases, 65 patients underwent surgical procedures (28 cases of radical resection,6 cases of palliative resection,31 cases of surgical drainage); 31 cases underwent inteventional drainage therapy, of them 18 cases had combined radiotherapy, and 15 cases and combined interventional chemotherapy. (1) The average survival time of the radical resection group, the palliative resection group and the surgical drainage group was 25 months, 15.5 months, and 11.5 months, respectively. There was a significant difference between the three groups (P＜0.01). (2) For the surgical drainage group, the average survival time was 11.5 months, which was not significantly greater than that of the interventional therapy group (11 months) (P＞0.05). (3) For the group of radical resection plus radiotherapy or chemotherapy, the average survival time was 27 months and 1-,3-,5-year survival rate was 75%,45%, and 15%, respectively, which was significantly greater than the group of radical resection without adding radio-therapy or chemotherapy (24 months, and 50%,12.5%,0, respectively) (P＜0.05).
Conclusions:The best prognosis can be achieved by radical excision for patient with hepatic hilar cholangiocarcinoma. There is similar effect between the surgical drainage and interventional therapy, but the method of interventional therapy is safer with less injury and is convenient with few complications. Postoperative chemotherapy and radiotherapy may help to extend patient’s survival time.