Abstract:Objective:To investigate the effects of oxamate on concentrations of calcium in pancreatic cancer cells.
Methods :Pancreatic cancer cell panc-1 was cultured in vitro with oxamate for 48 h, then stained with Fluo-3/AM, and the light density of cells for different concentration of oxamate under confocal laser microscopy was observed.
Results:Oxamate influenced the concentration of calcium in panc-1,and this effect corresponded to the concentration of oxamate.
Conclusions:Oxamate can induce the increase of the concentration of calcium of panc-1,and then influence the cellular pathophysiologic process.