Abstract:Objective:To study the effect of glutamine and arginine in rats with hepatic fibrosis.
Methods :Thirty male Wistar rats with hepatic fibrosis induced by CCl4 for 6 weeks were randomly divided into control group(n=10)、glutamine treatment group(n=10) and arginine treatment group(n=10). At 8 weeks after treatment, the liver appearance、collagen protein level and the degree of hepatic fibrosis were observed.
Results:At the end of 8 weeks,there was no death of any group of the rats.The glutamine group showed the most severe hepatic fibrosis, the control group showed less, and the arginine group showed the least fibrosis.
Conclusions:The degree of hepatic fibrosis is aggravated by glutamine, while arginine obviously relieves rat hepatic fibrosis.