Abstract:Objective:To study the diagnosis, treatment and prognostic factors of solid and pseudopapillary tumor of the pancreas (SPTP) in domestic.
Methods :Eight cases with SPTP in our hospital and a review of 397 others from the literature of China were analyzed. Clinical, radiographic and pathologic features were collected, and influence facters of prognosis were evaluated
Results:The patients (91.36% women) were of mean age 26.76 years; 40.99% of the patients were without subjective symptoms. CT was more precise than ultrasonography in determining tumor nature and location. The tumors were evenly distributed in the head/neck and body/tail of the pancreas. Surgery was the main therapeutic approach; 3.71% patients developed postoperative pancreatic fistula usually after local resection. Pathology was the definitive diagnostic method. Most tumors were positive for vimentin, α-antitrypsin and α-antichymotrysin, while negative for insulin, glucagon and CEA. Disease-free survival of mean 23.5 month was achieved in 95.40% cases after initial or second surgery. Tumor advanced in 5.02% of the patients. In our center, 62.50% of cases had been infected by HBV.
Conclusions:SPTP mainly occurred in young females and is a potentially low-malignancy tumor. Preoperative diagnosis is made through CT exam and postoperative diagnosis is confirmed by immunochemistry and pathology. Surgery is the predominant and effective method of treatment. Probable prognostic factors include gender, surgical modality and integrity of tumor capsule.