Abstract:Objective:To investigate the safety of different concentrations of FK506 for patients underging living donor liver transplantation (LDLT).
Methods :The clinical data of 46 LDLT recipients in recent 5 years were analyzed. The safety,immune complications and survival rate 1 month and 1 year after LDLT between the low concentration of FK506 (3-5ng/mL, 1year later 1-2 ng/mL) group and that of normal level (10-15 ng/mL, 1year later. 5-8 ng/mL) group were compared.
Results:At 1 month posttransplantation, the occurrence of acute rejection, hypertension,hyperglycemia and liver function was not significantly different between the two groups. Infection rate and serum creatinine level was significantly lower in low concentration groups than normal concentration groups at 1 month and 1 year. The graft survival rate was not different between the two groups at 1 month and 1 year.
Conclusions:A low concentration of FK506 in perioperative and long-term period is safe. The infection rate and the level of serum creatinine after transplantation are positively related to blood concentration of FK506.