Objective:To analyze the clinicopathologic factors related to the prognosis of gallbladder carcinoma.
Methods :A retrospective analysis was conducted on 61 cases of advanced gallbladder carcinoma who were operated on from 2001 to 2006 in Nanjing First Hospital.
Results:According to the 6th UICC/AJCC TNM classification and staging of gallbladder carcinoma, of the 61 patients, 8 patients were stage IB, 22 were IIA, 11 were IIB, 14 were III and 6 were IV. Palliative cholecystectomy and/or bile duct drainage procedures were performed in 24 patients; removal of gallbladder plus regional lymph nodes and fatty tissue dissections were performed in 14 cases; radical resection was performed in 7 patients; removal of gallbladder and part of liver in combination with resection of bile duct (radical operatian) was performed in 13 patients; 1 patient had extensive radical operation including pancreaticoduodenectomy. In 37 patients, 18 had positive lymph node metastasis. Fifty-two patients were followed up, 41（67.2%） patients were alive at 6 months after operation, 26（42.6%）were alive at 12 months, 10（16.4%） were alive at 24 months, and 7 cases were alive at 36 months, 1 patient is still alive 5 years after operation; 51 patients died within 2 years after operation. The symptoms of recurrence in 31 patients included progressing jaundice (21 cases), metastasis in liver (14 cases), and refractory ascites (12 cases). Five patients died of non- bile duct disease.
Conclusions:The prognosis of gallbladder cancer has a close relationship with the clinical stage and method of resection.