Objective:To study the correlation of early glucose metabolism and inflammatory factors in rats with acute peritoneal infection.Methods:Rats were randomly divided into 4 groups:A group,rats subjected to cecal ligation plus puncture(CLP); B group, to intraperitoneal injection of lipopolysaccharide(LPS);C group, to CLP combined with intraperitoneal injection of LPS C;D group,control group.A、B、C group all were to produce acute peritoneal infection. The blood glucose, TNF-α and IL-6 and insulin were detected, and insulin resistance index(IRI) was calculated to evaluate the extent of insulin resistance.Results:Blood glucose level and IRI were elevated in the early stage in A、B、C groups,and reached a peak level at 6 h. IRI changes in the early stage had a positive correlation with TNF-α and IL-6. The rats that received LPS injection presented (B、C groups) mainly had a higher level of IL-6. And 1L-6 evaluated persisted longer than TNF-α did.Conclusions:Our results suggest that insulin resistance can occur in the early stage of acute peritoneal infection. Although differences exist in their action time, both TNF-α and IL-6 have a positive relationship with insulin resistance.