Objective:To study the value of pancreaticoduodenectomy in combination with portal vein (PV) resection and reconstruction in the treatment of pancreatic carcinoma.Methods:The clinical data of 21 patients who received pancreaticoduodenectomy in combination with PV resection and reconstruction in the treatment of pancreatic carcinoma in our hospital in the past 6 years were retrospectively analyzed.Results:Perioperative complication incidence was 19.04% (4/21) and mortality rate was 4.76% (1/21). The major complications included delayed gastric emptying (9.52%), gastrointestinal bleeding (4.76%) and disruption of wound (4.76%), but no pancreatic leakage was observed. The survival time of 20 subjects ranged from 6 to 67 months ［mean (20.38±9.36) month］. The survival rate at 1y, 3y and 5y of the 21 subjects in this study were respectively 65.9%,16.0%,10.2%.Conclusions:Conduction of en bloc resection with the invaded PV/ SMV is safe and feasible for patients with locally advanced pancreatic adenocarcinoma. Major vascular resection can increase the resection rate, improve life quality and extend patient survival time.