Objective:To investigate the effect of various operative methods for pancreatic cancer on patient′s quality of life and survival time.
Methods:The clinical data of 142 patients with pancreatic cancer admitted into our hospital between 1997 and 2007 were analyzed retrospectively.The patients were divided into 3 groups:Undergoing radical resection(RR,n=38), palliative resection(PR,n=15) and biliary-jejunostomy(BJ,n=89). The BJ patients were subdivided into cholecystojejunostomy group(n=56)、 choledochojejunostomy group(n=33), gastrojejunostomy group(n=32) and no-gastrojejunostomy group(n=57) according to the differen methods of anastomosis. SPSS13.0 software package was used for survival analysis, the recurrence rate of jaundice and obstruction of duodenum.Results:The median survival time in patients undergoing RR、PR and BJ was 13.6、10.7 and 7.8 months respectively. RR group had longer survival time than PR and BJ group (P<0.01). Meanwhile,PR group had longer survival time than BJ group,but the difference was no statisfical (P>0.05) The patients receiving choledochojejunostomy had longer survival time than the patients undergoing cholecystojejunostomy(P<0.05). Moreover, the former had lower recurrence rate of jaundice than the latter(P<0.01). The gastrojejunostomy group had lower rate of duodenumal obstruction(P<0.05).Conclusions:Radical resection should be regarded as the first choice for the patients with pancreatic cancer. For those patients who cannot urdergo radical resection, the selection of biliary-jejunostomy and gastrojejunostomy(double bypass) is more conducive to better quality of life and longer survival time.