Although the concept of enhanced recovery after surgery (ERAS) has been rapidly acknowledged and widely used in China, it has encountered a series of practical problems in clinical application. Therefore, it is particularly necessary to carry out research on the ERAS clinical pathway for hepatopancreatobiliary surgical diseases according to the specific situations of hospitals at all levels in Hunan province. The Medical Administration Division of Hunan Provincial Health Commission, the Hepatobiliary Surgery Professional Committee of Hunan Medical Association, the Professional Committee of Enhanced Recovery After Surgery of Hunan Health Management Association, the Hepatobiliary Surgery Professional Committee of Hunan International Medical Exchange and Promotion Association, and the Hunan Alliance of Hepatobiliary and Pancreatic Surgery organized relevant experts in Hunan province to jointly discuss and developed the guiding principles for the clinical application of ERAS concept, and the data collection and case inclusion criteria of ERAS clinical pathway for hepatopancreatobiliary surgical diseases, and put forward the expert consensus on the clinical pathway for hepatopancreatobiliary surgical diseases in accordance with the actual situation in Hunan province, which provides reference and guidance for further promoting the implementation and application of ERAS concept normatively and orderly in the clinical practice of hepatopancreatobiliary surgery in Hunan province.