Objective:To explore the effective methods for therapy of deep vein thrombosis of lower extremity(DVT).
Methods:We conducted a retrospective analysis of 411 patients with DVT  treated in our hospital from 2004 to 2009.In 8 cases with significant contraindications for thrombolysis and anticoagulation, only symptomatic local treatment for swelling was used. Combined therapy including thrombolysis,anticoagulation,and anti-platelet adhesion therapy was used in 391 cases, and combined therapy and thrombectomy with Fogarty catheter was used in 12 cases. Permanent implantation of inferior vena cava filter(IVCF)was done in 21 cases.
Results:The changes in clinical signs and symptoms were satisfactory in 382 cases,28 cases had no significant effect from therapy or had complications,and 1 case died.A total of 184（44.8%）cases were follow-up for 4-62 months(average 20 months),the results showed that 32 cases were excellent(17.4%),107 good（58.2%）, 42（22.8%） mild improment, and 3 no changes（1.6%）.
Conclusions: Combined therapy with thrombolysis,anticoagulation,and anti-platelet adhesion therapy is effective and safe  for treatment of DVT. Early thrombectomy could improve patients′ prognosis remarkably,and IVCF is an effective measure to prevent pulmonary embolism.