Objective: To investigate the effects and mechanisms of extraction centipede extraction (CE) on grafting hepatocellular carcinoma (HCC) in nude mice.
 Methods: We set up model of  Bel-7404 cells heterotopic grafting HCC in nude mice, and  observed the tumor growth and metastasis after intragastric administration of CE (treatment group).  Immunohistochemical methods were used to detect X-chromosome linked inhibitor of apoptosis protein（XIAP）,bax gene,vascular endothelial growth factor(VEGF) and angiopoietin-2(Ang-2) in tumor tissue.
 Results:  There was distinctive inhibitive effect of CE on in Bel-7404 cells heterotopic grafting HCC in nude mice. The staining cells population，staining intensity and the optical density（OD）of XIAP,VEGF and Ang-2 in the control group were higher than those in treatment group, but those of BAX were lower than that in treatment group, and there was significant difference between the 2 groups（P＜0.05）.
 Conclusions: CE can inhibit the growth of heterotopic grafting HCC in nude mice, and the mechanisms may be related to inhibition of tumor angiogenesis  and promotion of apoptosis of HCC.