Objective: To investigate the diagnosis and treatment of secondary sclerosing cholangitis after billary tract operation.
 Methods: The clinical clata of 7 cases with secondary sclerosing cholangitis after billary tract operation treated in our hospital from January 2000 to June 2008 were retrospectively analyzed.
 Results: Recurrent episodes of bacterial cholangitis were present in all patients, and they all had history of biliary tract operation. After definite diagnosis, 2 cases underwent operation and 5 cases underwent conservative treatment. Among the latter, 1 case underwent endoscopic sphincterotomy and 1 case had liver transplantation. Of all the patients, 2 cases recovered(2/7), 2 cases died(2/7) and 3 cases are still undergoing treatment.
 Conclusions: The prognosis of secondary sclerosing cholangitis after billary tract operation is relatively poor. The key measure is prevention, and early diagnosis together with rational treatment can have certain therapeutic effect.