Objective:To study the effect of Qing Yi Tang (QYT) on bacterial and endotoxin translocation from intestine in acute hemorrhagic necrotizing pancreatitis (AHNP) in rats.
Methods:SD rats were  randomly divided into 3 groups: AHNP group, AHNP +QYT treatment group and sham operation(SO) group. AHNP models were set up in the former two group, while the pancreas was only mobilized in SO group. After setting up the model, QYT was gavaged in the QYT group, while normal saline was gavaged in the SO group and AHNP group. The concentration of  endotoxin(ET) and the DNA of E. coli expressoin in portal vein blood in three groups of rats were measured 24h later.
Results:The concentration of ET and amount of E.coli DNA in portal vein of QYT group were lower than those of  AHNP group.
Conclusions:QYT can reduce significantly the concentration of ET and E.coli DNA in portal vein blood and decrease bacterial and endotoxin translocation from intestine in the AHNP rats.