Objective:To study the efficiency enhancement and toxicity reduction effects of scutellaria barbata polysaccharides (SBPS) on mice treated with cytoxan (CTX).
Methods:Transplanted H 22 hepatoma mice were randomly divided into negative control group, CTX group and combined SBPS and CTX group. After 10 d of consecutive drug administration, the tumor inhibitory rate, blood  white cell count, phagocytic index and activity of IL-2 were measured.
Results:SBPS increased the tumor inhibitory rate and reduced the toxicity of cytoxan, and enhanced the function of mononuclear phagocytes and the activity of IL-2 and TNF-α.
Conclusions:SBPS has efficiency enhancement and toxicity reduction effects on cytoxan, and the mechanism may be by increasing the immunologic function of the organism.