Objective:To investigate clinical features and clinical experience of diagnosis and treatment of solid-pseudopapillary tumor of the pancreas (SPTP).
Methods:The clinical records of  757 cases of SPTP were analyzed retrospectively, which included 748 cases concerning SPTP published in Chinese medical journals and 9 cases of SPTP admitted to our hospital.
Results:Among the patients, 66 were males, 691 were females, and the mean age was 26.6 years. Major clinical manifestations were abdominal pain or discomfort (45.3%) and palpable abdominal masses (35.5%),but some cases (22.0%) were completely asymptomatic and the lesions were detected by routine examinations. In 95.9% of cases,  B ultrasonic examinations could detect the tumors，but the accuracy for judging the location of tumors by CT(87.5%) and MRI(90%) was better than that by B ultrasonic exam (71.2%). The tumors were often located in the head (39.1%) or the body and tail (54.1%) of the pancreas. The main treatment for SPTP was surgical procedure including enucleation (34.1%), pancreatoduodenectomy (23.7%) and distal pancreatectomy with splenectomy (22.5%).It was found that 60.3% of the tumors were solid and cystic, had complete capsule, and had a mean diameter of 8.0 cm.Among the 458 cases that were followed up, 450 cases were alive, including 3 cases with recurrences, 3 cases treated with tumor reductive surgery and 1 case with hepatic metastases after surgery. Of the 450 cases 8 died.
Conclusions:SPTP occurs predominantly in young females. Surgical procedure is the main effective treatment, and the prognosis is good, even for the cases with metastases or recurrences, the aggressive surgical therapy is good.