Objective：To discuss the features and prevention of central venous catheter infection in patients undergoing digestive tract operation.
Methods：The clinical data of 145 patients with central venous catheters after G1 surgery in our hospital from March 2004 to March 2009 were retrospectively analyzed. 
Results：Among the 145 cases with central venous catheters, 40 cases(27.6%)presented with defite catheter related infection and 56 strains of pathogens were isolated and cultured. Of the 56 isolates, 28 (50%) were of gram-negative bacteria, 22(39%) of gram-postive bacteria and 6(11%) of fungi. Six cases suffered from multiple catheter infection(15%),39patients were cured and 1 died.
Conclusions：Gram-negative bacteria are the most common pathogens for central venous catheter infection in GI operated patients. It is crucial that standardized card of intravenous infusion should be implemented and prophylactic antibiotics should properly be selected for control of enterogenous infection.