Objective：To investigate expression of C-MET in palliary thyroid carcinoma (PTC) detected by rapid immunohistochemical analysis and its clinical significance to predicting lymph node metastases.
Methods：The expression level of C-MET was examined by rapid immunohistochemical analysis with C-MET-EPOS antibody in 85 cases of PTC.
Results：The rate of cervical lymph node metastates in PTC with strong positive stain expression(95.0%, 23/25) was significantly higher than in PTC with positive stain expression(13.4%, 8/60) (P＜0.001).
Conclusions：Intense c-Met expression is an indicator of the presence of the cervical lymph node metastases. C-Met expression by rapid immunohistochemical analysis is a significant indicator for estimation  of cervical lymph node metastates and  choice of operative methods.