Objective：To study the therapeutic effects and prognosis of advanced pancreatic carcinoma treated with iodine-125 seeds implantation.
Methods：The records of 98 patients with unresectable advanced pancreatic carcinoma admitted from Mar. 2004 to Oct. 2008 were analyzed. There were 53 cases treated by supportive treatment, 24 cases by palliative operation and 21cases by palliative operation combined with iodine-125 seed implantation.
Results：Pain partial and complete relief rate in palliative operation combined with iodine-125 seeds implantation radiotherapy group(84.21% and 15.79%,respectively) was better than other two treatment groups(P＜0.05). The median survival time in combined group was 8.6 months, which was significantly longer than that of other two groups (4.5 month and 5.7 months respectively)(P＜0.05).
Conclusions：Palliative operation combined with iodine-125 seeds implantation could improve the prognosis of advanced pancreatic carcinoma. This combined therapy has certain therapeutic effects for advanced pancreatic carcinoma  in releiving pain, improving life quility and increasing survival time.