Objective：To discuss the clinical effect of two different routes of thrombolysis for the treatment of acute deep vein thrombosis (DVT).
Methods：A total of 126 patients with DVT during December 2005 to March 2010 were randomly divided into two groups: (1)transcatheter popliteal vein thrombolysis method (group A); (2)thrombolysis therapy via peripheral vein (group B). The venous patency score and patency improvement were observed by venograms or Duplux.
Results：After treatment, the reduction rate of edema of leg (0.82±0.14)% and of thigh(0.89±0.07)%, and the venous patency improvement rate (55.41±3.21)% in group A were significantly higer than those in thrombol group B（0.63±0.11）%，（0.57±0.09）%and （32.34±3.77）%, respectively (all P<0.05-0.01).
Conclusions：This results suggest that recovery rate and long term results of transcatheter popliteal vein  thrombolysis therapy is better than that of thrombolysis therapy via peripheral vein.